The Contribution of the Anticholinester Pedialanthus Tithymaloide to Its Mollusc

Experiments were conducted to evaluate the mo activity of aqueous leaf and stem-bark extract of Pe Euphorbiaceae) Lymnaea (Radix) acuminata (Lamar (Deshyas) – intermediate hosts of endemic schistosom cattle and livestock. The toxic effect of both extracts wa There was a significant negative correlation between observed, thus the LC10 values of P. tithymaloide leaf de 15.4 mg/L (96 h); LC50 decreased from 69.4 mg/L (2 decreased from 194.6 mg/L (24 h) to 48.9 mg/L (96 h values of P. tithymaloide leaf decreased from 5.5 mg/L decreased from 35.8 mg/L (24 h) to 4.3 mg/L (96 h); LC h) to 32.1 mg/L (96 h) against Indoplanorbis exustus. S the aqueous stem-bark extract of P. tithymaloide. Sub-l the aqueous leaf and stem-bark extract of P. tithymalo timeand dose-dependent inhibition of the activity of en in the nervous and hepatopancrease tissues of L. acum periods. Withdrawal study also shows that there wa acetylcholinesterase activity in both the tissues of snail of treatment. Thus, the aqueous extract of P. tithy environmentally safe candidate molluscicides for schistosomiasis and fascioliasis.